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Read the June 2017 Issue!
About the cover: Figure 2D from "The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors," by Zhang, et al.
Editor's Pick: Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor
Casey G. Langdon, et al.
Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles
Nicolas Floc'h, et al.
The Role of CtBP1 in Oncogenic Processes and Its Potential as a Therapeutic Target
Melanie A. Blevins, et al.

From the Current Issue

Reviews

The Role of CtBP1 in Oncogenic Processes and Its Potential as a Therapeutic Target

Melanie A. Blevins, Mingxia Huang and Rui Zhao

Mol Cancer Ther June 1 2017 16 (6) 981-990; DOI:10.1158/1535-7163.MCT-16-0592
Small Molecule Therapeutics | AuthorChoice

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Timothy P.S. Perera, Eleonora Jovcheva, Laurence Mevellec, Jorge Vialard, Desiree De Lange, Tinne Verhulst, Caroline Paulussen, Kelly Van De Ven, Peter King, Eddy Freyne, David C. Rees, Matthew Squires, Gordon Saxty, Martin Page, Christopher W. Murray, Ron Gilissen, George Ward, Neil T. Thompson, David R. Newell, Na Cheng, Liang Xie, Jennifer Yang, Suso J. Platero, Jayaprakash D. Karkera, Christopher Moy, Patrick Angibaud, Sylvie Laquerre and Matthew V. Lorenzi

Mol Cancer Ther June 1 2017 16 (6) 1010-1020; DOI:10.1158/1535-7163.MCT-16-0589
Large Molecule Therapeutics

A Fas Ligand (FasL)-Fused Humanized Antibody Against Tumor-Associated Glycoprotein 72 Selectively Exhibits the Cytotoxic Effect Against Oral Cancer Cells with a Low FasL/Fas Ratio

Ming-Hsien Chien, Wei-Min Chang, Wei-Jiunn Lee, Yu-Chan Chang, Tsung-Ching Lai, Derek V. Chan, Rahul Sharma, Yuan-Feng Lin and Michael Hsiao

Mol Cancer Ther June 1 2017 16 (6) 1102-1113; DOI:10.1158/1535-7163.MCT-16-0314
Cancer Biology and Signal Transduction

Focal Adhesion Kinase as a Potential Target in AML and MDS

Bing Z. Carter, Po Yee Mak, Xiangmeng Wang, Hui Yang, Guillermo Garcia-Manero, Duncan H. Mak, Hong Mu, Vivian R. Ruvolo, Yihua Qiu, Kevin Coombes, Nianxiang Zhang, Brittany Ragon, David T. Weaver, Jonathan A. Pachter, Steven Kornblau and Michael Andreeff

Mol Cancer Ther June 1 2017 16 (6) 1133-1144; DOI:10.1158/1535-7163.MCT-16-0719
Companion Diagnostics and Cancer Biomarkers

PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells

Wangyu Cai, Gang Chen, Qicong Luo, Jun Liu, Xiaofeng Guo, Tian Zhang, Fei Ma, Liang Yuan, Boan Li and Jianchun Cai

Mol Cancer Ther June 1 2017 16 (6) 1187-1198; DOI:10.1158/1535-7163.MCT-16-0750

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Recent Reviews

Reviews

Hey Factors at the Crossroad of Tumorigenesis and Clinical Therapeutic Modulation of Hey for Anticancer Treatment

Zihao Liu, Andrew J. Sanders, Gehao Liang, Erwei Song, Wen G. Jiang and Chang Gong

Mol Cancer Ther May 1 2017 16 (5) 775-786; DOI:10.1158/1535-7163.MCT-16-0576
Reviews

Nodal Signaling as a Developmental Therapeutics Target in Oncology

Aparna Kalyan, Benedito A. Carneiro, Sunandana Chandra, Jason Kaplan, Young Kwang Chae, Maria Matsangou, Mary J.C. Hendrix and Francis Giles

Mol Cancer Ther May 1 2017 16 (5) 787-792; DOI:10.1158/1535-7163.MCT-16-0215
Review | AuthorChoice

MET in Lung Cancer: Biomarker Selection Based on Scientific Rationale

Ravi Salgia

Mol Cancer Ther April 1 2017 16 (4) 555-565; DOI:10.1158/1535-7163.MCT-16-0472

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