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Read the April 2018 Issue!
Read the April 2018 Issue!
Editor's Pick: Relative Target Affinities of T-Cell–Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model
Danielle Mandikian, et al.
Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, in EGFR-Mutated Non–Small Cell Lung Cancer
Toshiyuki Hirano, et al.
JAK2 Inhibitor SAR302503 Abrogates PD-L1 Expression and Targets Therapy-Resistant Non–small Cell Lung Cancers
Sean P. Pitroda, et al.

From the Current Issue

Review

Engaging Anaphase Catastrophe Mechanisms to Eradicate Aneuploid Cancers

Masanori Kawakami, Lisa Maria Mustachio, Xi Liu and Ethan Dmitrovsky

Mol Cancer Ther April 1 2018 17 (4) 724-731; DOI:10.1158/1535-7163.MCT-17-1108
Small Molecule Therapeutics | AuthorChoice

JAK2 Inhibitor SAR302503 Abrogates PD-L1 Expression and Targets Therapy-Resistant Non–small Cell Lung Cancers

Sean P. Pitroda, Melinda E. Stack, Gene-Fu Liu, Sui-Sui Song, Lucy Chen, Hua Liang, Akash D. Parekh, Xiaona Huang, Paul Roach, Mitchell C. Posner, Ralph R. Weichselbaum and Nikolai N. Khodarev

Mol Cancer Ther April 1 2018 17 (4) 732-739; DOI:10.1158/1535-7163.MCT-17-0667
Large Molecule Therapeutics

Relative Target Affinities of T-Cell–Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model

Danielle Mandikian, Nene Takahashi, Amy A. Lo, Ji Li, Jeffrey Eastham-Anderson, Dionysos Slaga, Jason Ho, Maria Hristopoulos, Robyn Clark, Klara Totpal, Kedan Lin, Sean B. Joseph, Mark S. Dennis, Saileta Prabhu, Teemu T. Junttila and C. Andrew Boswell

Mol Cancer Ther April 1 2018 17 (4) 776-785; DOI:10.1158/1535-7163.MCT-17-0657
Cancer Biology and Translational Studies

Wnt/β-Catenin Pathway Activation Mediates Adaptive Resistance to BRAF Inhibition in Colorectal Cancer

Guangming Chen, Chenxi Gao, Xuan Gao, Dennis Han Zhang, Shih-Fan Kuan, Timothy F. Burns and Jing Hu

Mol Cancer Ther April 1 2018 17 (4) 806-813; DOI:10.1158/1535-7163.MCT-17-0561
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

MCT4 Expression Is a Potential Therapeutic Target in Colorectal Cancer with Peritoneal Carcinomatosis

Hee Kyung Kim, InKyoung Lee, Heejin Bang, Hee Cheol Kim, Woo Yong Lee, Seong Hyeon Yun, Jeeyun Lee, Su Jin Lee, Young Suk Park, Kyoung-Mee Kim and Won Ki Kang

Mol Cancer Ther April 1 2018 17 (4) 838-848; DOI:10.1158/1535-7163.MCT-17-0535
Models and Technologies

Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma

Jeremy M. Brownstein, Amy J. Wisdom, Katherine D. Castle, Yvonne M. Mowery, Peter Guida, Chang-Lung Lee, Francesco Tommasino, Chiara La Tessa, Emanuele Scifoni, Junheng Gao, Lixia Luo, Lorraine Da Silva Campos, Yan Ma, Nerissa Williams, Sin-Ho Jung, Marco Durante and David G. Kirsch

Mol Cancer Ther April 1 2018 17 (4) 858-868; DOI:10.1158/1535-7163.MCT-17-0965

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Recent Reviews

Review

Histone Methyltransferase EZH2: A Therapeutic Target for Ovarian Cancer

Bayley A. Jones, Sooryanarayana Varambally and Rebecca C. Arend

Mol Cancer Ther March 1 2018 17 (3) 591-602; DOI:10.1158/1535-7163.MCT-17-0437
Review

Path toward Precision Oncology: Review of Targeted Therapy Studies and Tools to Aid in Defining “Actionability” of a Molecular Lesion and Patient Management Support

Young Kwang Chae, Alan P. Pan, Andrew A. Davis, Sandip P. Patel, Benedito A. Carneiro, Razelle Kurzrock and Francis J. Giles

Mol Cancer Ther December 1 2017 16 (12) 2645-2655; DOI:10.1158/1535-7163.MCT-17-0597
Review

New B7 Family Checkpoints in Human Cancers

Ling Ni and Chen Dong

Mol Cancer Ther July 1 2017 16 (7) 1203-1211; DOI:10.1158/1535-7163.MCT-16-0761

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